Reduction of alkylindoles with sodium borohydride-aluminium chloride in pyridine.
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منابع مشابه
The reduction of cozymase by sodium borohydride.
Cozymase (diphosphopyridine nucleotide, DPN) has been assayed by a variety of biochemical and chemical methods (1). Among the simplest procedures has been the determination of the light absorption of reduced DPN at 340 rnp after reduction by sodium hydrosulfite. Since special precautions are required to remove completely the excess reducing agent which absorbs in this region, it appeared advant...
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Sodium borohydride is a well known reducing agent. In methanol at room temperature formyl and keto groups are readily reduced to alcohol groups, while ester and carboxyl groups, carbon-carbon and carbon-nitrogen double bonds are only reduced with difficulty (2, 17). Of the groups present in chlorophyll b the C3 formyl and the C9 keto groups should be amenable to reduction, while the C2 vinyl an...
متن کاملInactivation of Tetracycline with Sodium Borohydride.
Recently we reported on the rapid inactivation of tetracycline by use of cupric-morpholine complex (Kaplan, Lannon, and Buckwalter, J. Pharm. Sci., 64, 163, 1965). This degradation procedure is used as part of an assay technique for kanamycin in the presence of tetracycline. We have since found that sodium borohydride (Metal Hydrides Inc., Beverly, Mass.) can substitute for cupric-morpholine co...
متن کاملReduction of oximes with sodium borohydride - copper ( II ) su lfate in methanol
Reduction of oxi me fu nctionality to amine is an important synthetic transformation . As ox imes are stable derivatives of carbonyl compounds, subsequent reduction to amines is an attractive two-step procedure for reductive ami nation . Red uction of oximes to amines can be performed by hydride reducing agents or by catalytic hydrogenation.' Among hydride reducing agents, lithium aluminium hyd...
متن کاملReductive Dehalogenation of a-Haloketones by Sodium Borohydride and Tin(II) Chloride in Tetrahydrofuran
The dehalogenation of a-haloketones and a-halocarbonyl compounds is an inevitable proce dure for the organic synthesis and these reductive dehalogenations have been often effected in organic syntheses. There have been various procedures for the purpose and these are obtained by zinc and acetic acid [1], sodium dithionite [2], titanium(III) chloride [3], organotin hydride [4], sodium hydrogen t...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1978
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.26.108